Scientific Publications

Our drug development programs are grounded in science and extensive research spanning many different areas, including neurology, inflammation, and autoimmune diseases.

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Scientific Publications

Our drug development programs are grounded in science and extensive research spanning many different areas, including neurology, inflammation, and autoimmune diseases.

Read the research

Featured

NAC blocks Cystatin C amyloid complex aggregation in a cell system and in skin of HCCAA patients

23 March 2021

SOCS-JAK-STAT Inhibitors and SOCS Mimetics as Treatment Options for Autoimmune Uveitis, Psoriasis, Lupus, and Autoimmune Encephalitis

26 October 2023

CLEC16A—An Emerging Master Regulator of Autoimmunity and Neurodegeneration

4 May 2023

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

17 November 2013

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

04 October 2023

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wdt_ID	Condition	Year	Journal	Citations Scale	Citations	Title	Link to Paper	Type	Patent	Authors	Publications
3615	Alzheimer´s Disease and Familial Dementia	2023	Alzheimer´s & Dementia	https://www.arctictherapeutics.com/wp-content/uploads/Blue-7.png	<10	Trans-ethnic Genomic Informed Risk Assessment for Alzheimer’s disease: An International Hundred K+ Cohorts Consortium Study	https://doi.org/10.1002/alz.13378	PEER-REVIEWED PAPER		Patrick M. Sleiman, Hui-Qi Qu, … Hakon Hakonarson … et al.	Alzheimer´s & Dementia Trans-ethnic Genomic Informed Risk Assessment for Alzheimer’s disease: An International Hundred K+ Cohorts Consortium Study Patrick M. Sleiman, Hui-Qi Qu, … Hakon Hakonarson … et al. 2023 Condition Alzheimer´s Disease and Familial Dementia Citations <10
3616	Alzheimer´s Disease and Familial Dementia	2022	US Patent	https://www.arctictherapeutics.com/wp-content/uploads/Blue-7.png	<10	Compositions and Methods for Treatment of Hereditary Cystatin C Amyloid Angiopathy (HCCAA) and Other Neurodegenerative Disorders Associated with Aberrant Amyloid Deposits	https://patents.google.com/patent/US20220347255A1/en	PATENT	YES	Hakon Hakonarson, Alvaro Gutierrez-Uzquiza & Michael March	US Patent Compositions and Methods for Treatment of Hereditary Cystatin C Amyloid Angiopathy (HCCAA) and Other Neurodegenerative Disorders Associated with Aberrant Amyloid Deposits Hakon Hakonarson, Alvaro Gutierrez-Uzquiza & Michael March 2022 Condition Alzheimer´s Disease and Familial Dementia Citations <10
3617	Alzheimer´s Disease and Familial Dementia	2022	JAMA Psychiatry	https://www.arctictherapeutics.com/wp-content/uploads/Blue-6.png	10-49	Copy Number Variant Risk Scores Associated with Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort	https://doi.org/10.1001/jamapsychiatry.2022.1017	PEER-REVIEWED PAPER		Aaron Alexander-Bloch, Guillaume Huguet, … Hakon Hakonarson ... et al.	JAMA Psychiatry Copy Number Variant Risk Scores Associated with Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort Aaron Alexander-Bloch, Guillaume Huguet, … Hakon Hakonarson ... et al. 2022 Condition Alzheimer´s Disease and Familial Dementia Citations 10-49
3618	Alzheimer´s Disease and Familial Dementia	2021	Nature Communications	https://www.arctictherapeutics.com/wp-content/uploads/Blue-4.png	100-249	Common Variants in Alzheimer’s Disease and Risk Stratification by Polygenic Risk Scores	https://doi.org/10.1038/s41467-021-22491-8	PEER-REVIEWED PAPER		de Rojas, I., Moreno-Grau, S., … Hakon Hakonarson ... et al.	Nature Communications Common Variants in Alzheimer’s Disease and Risk Stratification by Polygenic Risk Scores de Rojas, I., Moreno-Grau, S., … Hakon Hakonarson ... et al. 2021 Condition Alzheimer´s Disease and Familial Dementia Citations 100-249
3619	Alzheimer´s Disease and Familial Dementia	2021	JAMA Neurology	https://www.arctictherapeutics.com/wp-content/uploads/Blue-4.png	100-249	Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-Analysis	https://doi:10.1001/jamaneurol.2020.3536	PEER-REVIEWED PAPER		Brian W Kunkle, Michael Schmidt, … Hakon Hakonarson ... et al.	JAMA Neurology Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-Analysis Brian W Kunkle, Michael Schmidt, … Hakon Hakonarson ... et al. 2021 Condition Alzheimer´s Disease and Familial Dementia Citations 100-249
3620	Alzheimer´s Disease and Familial Dementia	2019	Neurobiology of Aging	https://www.arctictherapeutics.com/wp-content/uploads/Blue-6.png	10-49	Genetic Risk for Alzheimer's Disease and Functional Brain Connectivity in Children and Adolescents	https://doi.org/10.1016/j.neurobiolaging.2019.06.011	PEER-REVIEWED PAPER		Luiza Kvitko Axelrud, João Ricardo Sato, … Hakon Hakonarson ... et al.	Neurobiology of Aging Genetic Risk for Alzheimer's Disease and Functional Brain Connectivity in Children and Adolescents Luiza Kvitko Axelrud, João Ricardo Sato, … Hakon Hakonarson ... et al. 2019 Condition Alzheimer´s Disease and Familial Dementia Citations 10-49
3621	Alzheimer´s Disease and Familial Dementia	2019	Nature Genetics	https://www.arctictherapeutics.com/wp-content/uploads/Blue-1.png	1000+	Genetic Meta-Analysis of Diagnosed Alzheimer’s Disease Identifies New Risk Loci and Implicates Aβ, Tau, Immunity and Lipid Processing	https://doi.org/10.1038/s41588-019-0358-2	PEER-REVIEWED PAPER		Brian W. Kunkle, Benjamin Grenier-Boley, … Hakon Hakonarson ... et al.	Nature Genetics Genetic Meta-Analysis of Diagnosed Alzheimer’s Disease Identifies New Risk Loci and Implicates Aβ, Tau, Immunity and Lipid Processing Brian W. Kunkle, Benjamin Grenier-Boley, … Hakon Hakonarson ... et al. 2019 Condition Alzheimer´s Disease and Familial Dementia Citations 1000+
3622	Alzheimer´s Disease and Familial Dementia	2018	American Journal of Psychiatry	https://www.arctictherapeutics.com/wp-content/uploads/Blue-5.png	50-99	Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life	https://doi.org/10.1176/appi.ajp.2017.17050529	PEER-REVIEWED PAPER		Luiza K Axelrud, Marcos L Santoro, … Hakon Hakonarson ... et al.	American Journal of Psychiatry Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life Luiza K Axelrud, Marcos L Santoro, … Hakon Hakonarson ... et al. 2018 Condition Alzheimer´s Disease and Familial Dementia Citations 50-99
3623	Alzheimer´s Disease and Familial Dementia	2018	BioRxiv	https://www.arctictherapeutics.com/wp-content/uploads/Blue-6.png	10-49	Meta-Analysis of Genetic Association with Diagnosed Alzheimer’s Disease Identifies Novel Risk Loci and Implicates Abeta, Tau, Immunity and Lipid Processing	https://doi.org/10.1101/294629	PREPRINT		Brian W Kunkle, Benjamin Grenier-Boley, … Hakon Hakonarson ... et.al.	BioRxiv Meta-Analysis of Genetic Association with Diagnosed Alzheimer’s Disease Identifies Novel Risk Loci and Implicates Abeta, Tau, Immunity and Lipid Processing Brian W Kunkle, Benjamin Grenier-Boley, … Hakon Hakonarson ... et.al. 2018 Condition Alzheimer´s Disease and Familial Dementia Citations 10-49
3624	Alzheimer´s Disease and Familial Dementia	2018	Alzheimer's & dementia: diagnosis, assessment & disease monitoring	https://www.arctictherapeutics.com/wp-content/uploads/Blue-7.png	<10	Genetically Elevated High‐Density Lipoprotein Cholesterol Through the Cholesteryl Ester Transfer Protein Gene Does Not Associate with Risk of Alzheimer's Disease	https://doi.org/10.1016/j.dadm.2018.08.008	PEER-REVIEWED PAPER		Gina M Peloso, Sven J Van Der Lee, … Hakon Hakonarson ... et al.	Alzheimer's & dementia: diagnosis, assessment & disease monitoring Genetically Elevated High‐Density Lipoprotein Cholesterol Through the Cholesteryl Ester Transfer Protein Gene Does Not Associate with Risk of Alzheimer's Disease Gina M Peloso, Sven J Van Der Lee, … Hakon Hakonarson ... et al. 2018 Condition Alzheimer´s Disease and Familial Dementia Citations <10
	Condition	Year			Citations			Type	Patent