Our science

We are advancing a robust pipeline of innovative therapeutics aimed at transforming patient care in neurology, inflammatory skin diseases, and autoimmune conditions. Our portfolio includes five programs each grounded in cutting-edge science and supported by a strong body of research.

Featured publications

Implications of the non-neuronal cholinergic system for therapeutic interventions of inflammatory skin diseases

18th October 204

N-Acetylcysteine for Hereditary Cystatin C Amyloid Angiopathy A Nonrandomized Clinical Trial

31st March 2025

Multi-ancestry Genome-Wide Association Meta-Analysis Identifies Novel Loci in Atopic Dermatitis 4

25th July 2024

Our approach

Our approach prioritizes therapies with the potential to be best-in-class, targeting significant unmet needs in major commercial markets. Program selection is driven by the strength of the scientific hypothesis and compelling supporting evidence, ensuring that each initiative has the potential to redefine standards of care and improve patient outcomes.

Explore our pipeline

Read the research

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wdt_ID	Condition	Year	Journal	Citations Scale	Title	Link to Paper	Authors	Publications
3615	Alzheimer´s Disease and Familial Dementia	2023	Alzheimer´s & Dementia	https://www.arctictherapeutics.com/wp-content/uploads/Blue-7.png	Trans-ethnic Genomic Informed Risk Assessment for Alzheimer’s disease: An International Hundred K+ Cohorts Consortium Study	https://doi.org/10.1002/alz.13378	Patrick M. Sleiman, Hui-Qi Qu, … Hakon Hakonarson … et al.	Alzheimer´s & Dementia Trans-ethnic Genomic Informed Risk Assessment for Alzheimer’s disease: An International Hundred K+ Cohorts Consortium Study Patrick M. Sleiman, Hui-Qi Qu, … Hakon Hakonarson … et al. 2023 Condition Alzheimer´s Disease and Familial Dementia Citations <10
3616	Alzheimer´s Disease and Familial Dementia	2022	US Patent	https://www.arctictherapeutics.com/wp-content/uploads/Blue-7.png	Compositions and Methods for Treatment of Hereditary Cystatin C Amyloid Angiopathy (HCCAA) and Other Neurodegenerative Disorders Associated with Aberrant Amyloid Deposits	https://patents.google.com/patent/US20220347255A1/en	Hakon Hakonarson, Alvaro Gutierrez-Uzquiza & Michael March	US Patent Compositions and Methods for Treatment of Hereditary Cystatin C Amyloid Angiopathy (HCCAA) and Other Neurodegenerative Disorders Associated with Aberrant Amyloid Deposits Hakon Hakonarson, Alvaro Gutierrez-Uzquiza & Michael March 2022 Condition Alzheimer´s Disease and Familial Dementia Citations <10
3617	Alzheimer´s Disease and Familial Dementia	2022	JAMA Psychiatry	https://www.arctictherapeutics.com/wp-content/uploads/Blue-6.png	Copy Number Variant Risk Scores Associated with Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort	https://doi.org/10.1001/jamapsychiatry.2022.1017	Aaron Alexander-Bloch, Guillaume Huguet, … Hakon Hakonarson ... et al.	JAMA Psychiatry Copy Number Variant Risk Scores Associated with Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort Aaron Alexander-Bloch, Guillaume Huguet, … Hakon Hakonarson ... et al. 2022 Condition Alzheimer´s Disease and Familial Dementia Citations 10-49
3618	Alzheimer´s Disease and Familial Dementia	2021	Nature Communications	https://www.arctictherapeutics.com/wp-content/uploads/Blue-4.png	Common Variants in Alzheimer’s Disease and Risk Stratification by Polygenic Risk Scores	https://doi.org/10.1038/s41467-021-22491-8	de Rojas, I., Moreno-Grau, S., … Hakon Hakonarson ... et al.	Nature Communications Common Variants in Alzheimer’s Disease and Risk Stratification by Polygenic Risk Scores de Rojas, I., Moreno-Grau, S., … Hakon Hakonarson ... et al. 2021 Condition Alzheimer´s Disease and Familial Dementia Citations 100-249
3619	Alzheimer´s Disease and Familial Dementia	2021	JAMA Neurology	https://www.arctictherapeutics.com/wp-content/uploads/Blue-4.png	Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-Analysis	https://doi:10.1001/jamaneurol.2020.3536	Brian W Kunkle, Michael Schmidt, … Hakon Hakonarson ... et al.	JAMA Neurology Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-Analysis Brian W Kunkle, Michael Schmidt, … Hakon Hakonarson ... et al. 2021 Condition Alzheimer´s Disease and Familial Dementia Citations 100-249
3620	Alzheimer´s Disease and Familial Dementia	2019	Neurobiology of Aging	https://www.arctictherapeutics.com/wp-content/uploads/Blue-6.png	Genetic Risk for Alzheimer's Disease and Functional Brain Connectivity in Children and Adolescents	https://doi.org/10.1016/j.neurobiolaging.2019.06.011	Luiza Kvitko Axelrud, João Ricardo Sato, … Hakon Hakonarson ... et al.	Neurobiology of Aging Genetic Risk for Alzheimer's Disease and Functional Brain Connectivity in Children and Adolescents Luiza Kvitko Axelrud, João Ricardo Sato, … Hakon Hakonarson ... et al. 2019 Condition Alzheimer´s Disease and Familial Dementia Citations 10-49
3621	Alzheimer´s Disease and Familial Dementia	2019	Nature Genetics	https://www.arctictherapeutics.com/wp-content/uploads/Blue-1.png	Genetic Meta-Analysis of Diagnosed Alzheimer’s Disease Identifies New Risk Loci and Implicates Aβ, Tau, Immunity and Lipid Processing	https://doi.org/10.1038/s41588-019-0358-2	Brian W. Kunkle, Benjamin Grenier-Boley, … Hakon Hakonarson ... et al.	Nature Genetics Genetic Meta-Analysis of Diagnosed Alzheimer’s Disease Identifies New Risk Loci and Implicates Aβ, Tau, Immunity and Lipid Processing Brian W. Kunkle, Benjamin Grenier-Boley, … Hakon Hakonarson ... et al. 2019 Condition Alzheimer´s Disease and Familial Dementia Citations 1000+
3622	Alzheimer´s Disease and Familial Dementia	2018	American Journal of Psychiatry	https://www.arctictherapeutics.com/wp-content/uploads/Blue-5.png	Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life	https://doi.org/10.1176/appi.ajp.2017.17050529	Luiza K Axelrud, Marcos L Santoro, … Hakon Hakonarson ... et al.	American Journal of Psychiatry Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life Luiza K Axelrud, Marcos L Santoro, … Hakon Hakonarson ... et al. 2018 Condition Alzheimer´s Disease and Familial Dementia Citations 50-99
3623	Alzheimer´s Disease and Familial Dementia	2018	BioRxiv	https://www.arctictherapeutics.com/wp-content/uploads/Blue-6.png	Meta-Analysis of Genetic Association with Diagnosed Alzheimer’s Disease Identifies Novel Risk Loci and Implicates Abeta, Tau, Immunity and Lipid Processing	https://doi.org/10.1101/294629	Brian W Kunkle, Benjamin Grenier-Boley, … Hakon Hakonarson ... et.al.	BioRxiv Meta-Analysis of Genetic Association with Diagnosed Alzheimer’s Disease Identifies Novel Risk Loci and Implicates Abeta, Tau, Immunity and Lipid Processing Brian W Kunkle, Benjamin Grenier-Boley, … Hakon Hakonarson ... et.al. 2018 Condition Alzheimer´s Disease and Familial Dementia Citations 10-49
3624	Alzheimer´s Disease and Familial Dementia	2018	Alzheimer's & dementia: diagnosis, assessment & disease monitoring	https://www.arctictherapeutics.com/wp-content/uploads/Blue-7.png	Genetically Elevated High‐Density Lipoprotein Cholesterol Through the Cholesteryl Ester Transfer Protein Gene Does Not Associate with Risk of Alzheimer's Disease	https://doi.org/10.1016/j.dadm.2018.08.008	Gina M Peloso, Sven J Van Der Lee, … Hakon Hakonarson ... et al.	Alzheimer's & dementia: diagnosis, assessment & disease monitoring Genetically Elevated High‐Density Lipoprotein Cholesterol Through the Cholesteryl Ester Transfer Protein Gene Does Not Associate with Risk of Alzheimer's Disease Gina M Peloso, Sven J Van Der Lee, … Hakon Hakonarson ... et al. 2018 Condition Alzheimer´s Disease and Familial Dementia Citations <10
	Condition	Year