
Our science
We are advancing a robust pipeline of innovative therapeutics aimed at transforming patient care in neurology, inflammatory skin diseases, and autoimmune conditions. Our portfolio includes five programs, each grounded in cutting-edge science and supported by a strong body of research.

Our approach prioritizes therapies with the potential to be best-in-class, targeting significant unmet needs in major commercial markets. Program selection is driven by the strength of the scientific hypothesis and compelling supporting evidence, ensuring that each initiative has the potential to redefine standards of care and improve patient outcomes.
Explore our publications to learn more about the research that fuels
our commitment to scientific excellence and therapeutic innovation.
Read the research
wdt_ID | Condition | Year | Journal | Citations Scale | Citations | Title | Link to Paper | Type | Patent | Authors | Publications |
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3615 | Alzheimer´s Disease and Familial Dementia | 2023 | Alzheimer´s & Dementia | https://www.arctictherapeutics.com/wp-content/uploads/Blue-7.png | <10 | Trans-ethnic Genomic Informed Risk Assessment for Alzheimer’s disease: An International Hundred K+ Cohorts Consortium Study | https://doi.org/10.1002/alz.13378 | PEER-REVIEWED PAPER | Patrick M. Sleiman, Hui-Qi Qu, … Hakon Hakonarson … et al. |
Alzheimer´s & Dementia Trans-ethnic Genomic Informed Risk Assessment for Alzheimer’s disease: An International Hundred K+ Cohorts Consortium Study Patrick M. Sleiman, Hui-Qi Qu, … Hakon Hakonarson … et al. 2023 Condition Alzheimer´s Disease and Familial Dementia Citations ![]() ![]() ![]() ![]() <10 |
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3616 | Alzheimer´s Disease and Familial Dementia | 2022 | US Patent | https://www.arctictherapeutics.com/wp-content/uploads/Blue-7.png | <10 | Compositions and Methods for Treatment of Hereditary Cystatin C Amyloid Angiopathy (HCCAA) and Other Neurodegenerative Disorders Associated with Aberrant Amyloid Deposits | https://patents.google.com/patent/US20220347255A1/en | PATENT | YES | Hakon Hakonarson, Alvaro Gutierrez-Uzquiza & Michael March |
US Patent Compositions and Methods for Treatment of Hereditary Cystatin C Amyloid Angiopathy (HCCAA) and Other Neurodegenerative Disorders Associated with Aberrant Amyloid Deposits Hakon Hakonarson, Alvaro Gutierrez-Uzquiza & Michael March 2022 Condition Alzheimer´s Disease and Familial Dementia Citations ![]() ![]() ![]() ![]() <10 |
3617 | Alzheimer´s Disease and Familial Dementia | 2022 | JAMA Psychiatry | https://www.arctictherapeutics.com/wp-content/uploads/Blue-6.png | 10-49 | Copy Number Variant Risk Scores Associated with Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort | https://doi.org/10.1001/jamapsychiatry.2022.1017 | PEER-REVIEWED PAPER | Aaron Alexander-Bloch, Guillaume Huguet, … Hakon Hakonarson … et al. |
JAMA Psychiatry Copy Number Variant Risk Scores Associated with Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort Aaron Alexander-Bloch, Guillaume Huguet, … Hakon Hakonarson … et al. 2022 Condition Alzheimer´s Disease and Familial Dementia Citations ![]() ![]() ![]() ![]() 10-49 |
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3618 | Alzheimer´s Disease and Familial Dementia | 2021 | Nature Communications | https://www.arctictherapeutics.com/wp-content/uploads/Blue-4.png | 100-249 | Common Variants in Alzheimer’s Disease and Risk Stratification by Polygenic Risk Scores | https://doi.org/10.1038/s41467-021-22491-8 | PEER-REVIEWED PAPER | de Rojas, I., Moreno-Grau, S., … Hakon Hakonarson … et al. |
Nature Communications Common Variants in Alzheimer’s Disease and Risk Stratification by Polygenic Risk Scores de Rojas, I., Moreno-Grau, S., … Hakon Hakonarson … et al. 2021 Condition Alzheimer´s Disease and Familial Dementia Citations ![]() ![]() ![]() 100-249 |
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3619 | Alzheimer´s Disease and Familial Dementia | 2021 | JAMA Neurology | https://www.arctictherapeutics.com/wp-content/uploads/Blue-4.png | 100-249 | Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-Analysis | https://doi:10.1001/jamaneurol.2020.3536 | PEER-REVIEWED PAPER | Brian W Kunkle, Michael Schmidt, … Hakon Hakonarson … et al. |
JAMA Neurology Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-Analysis Brian W Kunkle, Michael Schmidt, … Hakon Hakonarson … et al. 2021 Condition Alzheimer´s Disease and Familial Dementia Citations ![]() ![]() ![]() 100-249 |
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3620 | Alzheimer´s Disease and Familial Dementia | 2019 | Neurobiology of Aging | https://www.arctictherapeutics.com/wp-content/uploads/Blue-6.png | 10-49 | Genetic Risk for Alzheimer’s Disease and Functional Brain Connectivity in Children and Adolescents | https://doi.org/10.1016/j.neurobiolaging.2019.06.011 | PEER-REVIEWED PAPER | Luiza Kvitko Axelrud, João Ricardo Sato, … Hakon Hakonarson … et al. |
Neurobiology of Aging Genetic Risk for Alzheimer’s Disease and Functional Brain Connectivity in Children and Adolescents Luiza Kvitko Axelrud, João Ricardo Sato, … Hakon Hakonarson … et al. 2019 Condition Alzheimer´s Disease and Familial Dementia Citations ![]() ![]() ![]() ![]() 10-49 |
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3621 | Alzheimer´s Disease and Familial Dementia | 2019 | Nature Genetics | https://www.arctictherapeutics.com/wp-content/uploads/Blue-1.png | 1000+ | Genetic Meta-Analysis of Diagnosed Alzheimer’s Disease Identifies New Risk Loci and Implicates Aβ, Tau, Immunity and Lipid Processing | https://doi.org/10.1038/s41588-019-0358-2 | PEER-REVIEWED PAPER | Brian W. Kunkle, Benjamin Grenier-Boley, … Hakon Hakonarson … et al. |
Nature Genetics Genetic Meta-Analysis of Diagnosed Alzheimer’s Disease Identifies New Risk Loci and Implicates Aβ, Tau, Immunity and Lipid Processing Brian W. Kunkle, Benjamin Grenier-Boley, … Hakon Hakonarson … et al. 2019 Condition Alzheimer´s Disease and Familial Dementia Citations ![]() ![]() 1000+ |
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3622 | Alzheimer´s Disease and Familial Dementia | 2018 | American Journal of Psychiatry | https://www.arctictherapeutics.com/wp-content/uploads/Blue-5.png | 50-99 | Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life | https://doi.org/10.1176/appi.ajp.2017.17050529 | PEER-REVIEWED PAPER | Luiza K Axelrud, Marcos L Santoro, … Hakon Hakonarson … et al. |
American Journal of Psychiatry Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life Luiza K Axelrud, Marcos L Santoro, … Hakon Hakonarson … et al. 2018 Condition Alzheimer´s Disease and Familial Dementia Citations ![]() ![]() 50-99 |
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3623 | Alzheimer´s Disease and Familial Dementia | 2018 | BioRxiv | https://www.arctictherapeutics.com/wp-content/uploads/Blue-6.png | 10-49 | Meta-Analysis of Genetic Association with Diagnosed Alzheimer’s Disease Identifies Novel Risk Loci and Implicates Abeta, Tau, Immunity and Lipid Processing | https://doi.org/10.1101/294629 | PREPRINT | Brian W Kunkle, Benjamin Grenier-Boley, … Hakon Hakonarson … et.al. |
BioRxiv Meta-Analysis of Genetic Association with Diagnosed Alzheimer’s Disease Identifies Novel Risk Loci and Implicates Abeta, Tau, Immunity and Lipid Processing Brian W Kunkle, Benjamin Grenier-Boley, … Hakon Hakonarson … et.al. 2018 Condition Alzheimer´s Disease and Familial Dementia Citations ![]() ![]() ![]() ![]() 10-49 |
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3624 | Alzheimer´s Disease and Familial Dementia | 2018 | Alzheimer’s & dementia: diagnosis, assessment & disease monitoring | https://www.arctictherapeutics.com/wp-content/uploads/Blue-7.png | <10 | Genetically Elevated High‐Density Lipoprotein Cholesterol Through the Cholesteryl Ester Transfer Protein Gene Does Not Associate with Risk of Alzheimer’s Disease | https://doi.org/10.1016/j.dadm.2018.08.008 | PEER-REVIEWED PAPER | Gina M Peloso, Sven J Van Der Lee, … Hakon Hakonarson … et al. |
Alzheimer’s & dementia: diagnosis, assessment & disease monitoring Genetically Elevated High‐Density Lipoprotein Cholesterol Through the Cholesteryl Ester Transfer Protein Gene Does Not Associate with Risk of Alzheimer’s Disease Gina M Peloso, Sven J Van Der Lee, … Hakon Hakonarson … et al. 2018 Condition Alzheimer´s Disease and Familial Dementia Citations ![]() ![]() ![]() ![]() <10 |
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Condition | Year | Citations | Type | Patent |